1.Development of ultra-high (THz) bandwidth photodetectors and photonic transmitters. 2.Development of THz/microwave fluidics for non-affinity-based bio- molecule sensing. 3.Confined acoustic vibration of nanoparticles, including viruses, and their dielectric coupling with EM waves. 4.THz fibers and THz fiber-endoscope for biomolecular imaging. 5.Femtosecond all solid state lasers in the telecom wavelengths. 6.Photonic crystal fibers for femtosecond light delivery & Raman soliton. 7.Fiber nonlinear endoscope for in vivo imaging. 8.MEMS based video rate microscopy. 9.Nonlinear nanoparticles for optical molecular imaging. 10.Nano-toxicology.